Making medicines affordable for everyone across America


Investors and executives urge the Congressional Budget Office to adopt changes to its modeling

January 17, 2024 - The Congressional Budget Office (CBO) is responsible for estimating the impact of new legislation. Last year, they estimated that the Inflation Reduction Act’s 9-year penalty would have little impact on innovation.
Our team of economists, investors, and researchers checked their math and found a mistake.
Read the full letter.

Are you working towards a career in biotech and making new medicines?

Students can apply for NPLB's fellowship program.


Learn how the IRA makes new small molecule R&D uninvestable for diseases of aging

to the detriment of patients, innovators, & society

Inventing new medicines is a long climb

Who creates new medicines? Publicly funded research creates the necessary "base camp" knowledge, but it takes teams of innovators working with the support of private funding to reach risky new summits and provide patients with new cures.

Our Call to Action

Leading biopharma Innovators, investors, and patient groups urged congress to solve affordability for patients through insurance reform. More than 300 industry leaders share ideas on how to save all Americans money while preserving research and development. Caution that government price controls will cease biopharma investment and significantly reduce availability of new medicines. Read what more here.

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Our Videos & Animation
Explore NPLB's core principles, positions and plans to make medicines affordable for all Americans, encourage innovation, and ensure that patients are heard.

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Our goals

Make sure that everyone in America has affordable healthcare they can actually use and guarantee that our country continues to invest in new medicines that will help patients now and in the future.

out-of-pocket costs

Expand insurance
to everyone

Ensure that all drugs go generic

All posts

Generalized Cost-Effectiveness Analysis to Assess Treatment Value in Hepatitis C

Incorporating GCEA values resulted in a 10-fold improvement compared to traditional CEA math

Ensuring Medicare Rx Price Negotiations Help Patients

Rx market savings are not reflected in CEAs and plans are not passing savings on to patients

The Importance of Accurately Measuring the Value of New Medications

Including factors, such as dynamic pricing, helps assess medication value better th

The Value of Care: Q&A With Peter Rubin, Executive Director at No Patient Left Behind

Rubin speaks about how drugs aren’t being properly valued.

ICER’s ‘updated’ methodology falls far short

ICER acknowledges that their math is flawed, but they don't fix their mistakes.

Report stresses value of innovative medicines to patients and society

critical flaws in a key metric used to determine whether to cover prescribed treatments

We're determined to help you get the care and medicines your doctors say you need.

We are dedicated to creating and maintaining patient access to affordable drugs by holding both insurance and pharmaceutical companies accountable for their policies and practices.

About us
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Affordability and Innovation

We are championing new laws to get insurance companies to do away with copays and out-of-pocket expenses.

We are pushing for reforms to guarantee that drug companies let their drugs go generic when they're supposed to do so.

Who we are

Explore our cause

Help for patients

Don’t despair. There’s help for you: assistance with copays, deductibles and other expenses.

Our strategy

Coalition building. Raising awareness. Encouraging innovation. Changing perceptions and policy. Making medicines affordable.

Our presentations

Clear-cut ideas and solutions. The science, economics and policy of affordability and innovation.

Did you know?

Increasing out-of-pocket costs by just $10 per prescription causes a 33% rise in mortality because fewer patients take the drugs their doctors prescribe.

Source: National Bureau of Economic Research, involved